Leukoglycemic index as predictor of in-hospital complications in acute myocardial infarction

Abstract

Objective: To evaluate the predictive capability of the leukoglycemic index of in-hospital complications in patients with acute  myocardial infarction with ST-segment elevation. Methods: A multi-center, observational, prospective, cohort study, with 507 patients admitted with acute myocardial infarction with ST-segment elevation since September 2013 to March 2020, at two  secondary care hospitals. In order to define the performance of the leukoglycemic index, discrimination was evaluated with the statistical C, and calibration by Hosmer - Lemeshow test. Results: The mean age was 61 ± 11.7 years; male sex predominated. Principal risk factors: Hypertension and tobacco addiction. In 285 patients there was inferior wall compromise, 59 patients presented Killip Kimball's classification ≥ II; 310 patients underwent fibrinolytic treatment and 101 patients had coronary angioplasty done. There were in-hospital complications in 198 patients; post-infarct angina was the more frequent. The leukoglycemic index presented a good calibration according to the test of Hosmer Lemeshow (χ2 = 6.197; p = 0.625), but its discriminating capability was bad, with an area under curve of 0.60 (95% IC 0.55 – 0.65; p = 0.001). Conclusions: The leukoglycemic index has a low performance for the prediction of the risk of in-hospital complications in acute myocardial infarction.