Correlation between mean platelet volume and aortic valve sclerosis

Abstract

Aortic valve sclerosis (AVS) is a progressive clinical state with fibro-calcification and thickening of the aortic valve, without considerable occlusion confirmed by echocardiography. Mean platelet volume (MPV) is a complete blood count index (CBC) that indicates platelet activity. Numerous studies have reported that there is a close correlation between MPV and risk factors for cardiovascular disease. The aim of this study was to establish the correlation between MPV and AVS in patients referred to the cardiology department of the Shahid Sadoughi hospital. Material and methods: After the echocardiographic evaluation of 134 patients for AVS, the patients were divided into two equal groups (positive AVS and negative AVS). Blood sampling was also performed. Echocardiographic data and serological findings were recorded as a questionnaire. SPSS 19 software was used for data analysis. Results: Higher average age, hypertension, hyperlipidemia and diabetes mellitus are risk factors for AVS. Gender, smoking, HDL, LDL, triglycerides and total cholesterol however could not predict AVS. Patients with positive AVS have higher MPV compared to patients with negative AVS (9.93 ± 0.729 vs. 9.6 ± 0.965; P value = 0.012). Conclusions: Diabetes mellitus, hypertension, hyperlipidemia and average age were recorded more frequently in patients with positive AVS compared to patients with negative AVS. There was a significant correlation between MPV and AVS.