Cardiac Amyloidosis. Redefining heart failure with preserved ejection fraction

Abstract

We present a 69-year-old patient who was hospitalized for heart failure of unknown cause. His echocardiogram revealed biventricular infiltrative cardiomyopathy, with preserved ejection fraction and global longitudinal Strain: severely depressed -8%. The studies carried out, magnetic resonance imaging and scintigraphy with 99mTc-Pyrophosphate strongly suggested transthyretin cardiac amyloidosis, confirmed histopathologically by endomyocardial biopsy. The important contribution of non-invasive imaging techniques, together with the development of specific therapies, highlight the importance of early identification of this pathology.