Combined antihypertensive therapies in patients with arterial hypertension and chronic obstructive pulmonary disease

Abstract

There are currently no multicentre studies evaluating the optimal antihypertensive combination for patients with comorbid pathology. Objective: To evaluate the comparative efficacy and safety of combined antihypertensive therapies in patients with hypertension and COPD. Material and methods: Patients with arterial hypertension and COPD were examined who had been prescribed different treatment regimens (amlodipine + perindopril or amlodipine + valsartan). The effectiveness of each treatment was determined based on a standard examination, daily monitoring of BP and ECG, quality of life indicators, and the frequency
of depression. Results: The use of either of the combined therapies to treat hypertension in patients with COPD contributes to the same improvement in quality of life, reduction in the frequency of depression, and decrease in the main BP parameters with a comparable frequency of side effects. Conclusion: The two combinations evaluated here, which demonstrated comparable efficacy and tolerance, are recommended as the first step in antihypertensive therapy for comorbid patients.